factor V Leiden

noun

factor V Lei·​den -ˈlī-dᵊn 

1

: a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood

2

also factor V Leiden thrombophilia : a genetic disorder caused by factor V Leiden that is marked by an increased risk of abnormal blood clot formation leading especially to deep vein thrombosis or pulmonary embolism

Note: Factor V Leiden is inherited as an autosomal dominant trait requiring that only one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. When both parents carry the defective gene, factor V Leiden is inherited as a recessive, more serious condition.